5
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T24269 | KPT-251 | KPT251 | Others |
KPT-251 is a selective nuclear export inhibitor. | |||
T15735 | Leptomycin B | CI 940,LMB | CRM1 , Antibiotic , Antifungal |
Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a ... | |||
T11766L | Eltanexor | ONO-7706,KPT-8602,ATG-016 | Others |
Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes ... | |||
T70180 | LFS-829 | ||
LFS-829 is a a small-molecule antagonist of exportin-1. LFS-829 showed low-range nanomolar activities. Oral administration of LFS-829 can significantly reverse the pathological features of colitis model mice. LFS-829 can... | |||
T11837 | Leptomycin A | CRM1 | |
Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the... |